Advanced Oncology Certified Nurse Practitioner (AOCNP) Certification Practice Test

Initiating preventative measures for Tumor Lysis Syndrome (TLS) should occur 24-48 hours prior to treatment. This timing is crucial because TLS can develop rapidly after the initiation of therapy in patients with hematologic malignancies or highly proliferative tumors. By implementing preventative measures in advance, healthcare providers can mitigate the risk factors associated with the syndrome, such as elevated potassium, phosphorus, and uric acid levels.

Additionally, this proactive approach allows time for monitoring and adjusting hydration, electrolyte replacement, and possibly using medications such as allopurinol or rasburicase to control uric acid levels. Starting these interventions early helps ensure the patient is in a stable condition before treatment begins, thus reducing the likelihood of symptomatic TLS and promoting a safer treatment experience.